Clinical Examination and Differential Diagnosis of Skin Lesions by Dan Lipsker

Author:Dan Lipsker
Language: eng
Format: epub
Publisher: Springer Paris, Paris

Fig. 15.44

Fig. 15.45

15.1.10 Cronkhite-Canada Syndrome

Pigmentation of the back of the hands associated with ­distal onycholysis and proximal separation of the nail plate (onychomadesis) (Fig. 15.46). It is a non-hereditary polyposis which rarely turns into cancer and is associated with a severe exudative bowel disease causing diarrhea ­accompanied by weight loss and edema. This syndrome is currently ­considered as an inflammatory disease. The cutaneous signs are common and quite characteristic: hyperpigmentation, particularly of the folds and palms (Fig. 15.47). Constant modifications of the appendages are nail appearing yellow and separated (xanthonychia and onycholysis) (Fig. 15.46) and alopecia.

Fig. 15.46

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